3alpha(or 20beta)-hydroxysteroid dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a 3alpha(or 20beta)-hydroxysteroid dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

androstan-3alpha,17beta-diol + NAD⁺ $\rightleftharpoons$ 17beta-hydroxyandrostan-3-one + NADH + H⁺

Thus, the two substrates of this enzyme are androstan-3alpha,17beta-diol and NAD⁺, whereas its 3 products are 17beta-hydroxyandrostan-3-one, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 3alpha(or 20beta)-hydroxysteroid:NAD⁺ oxidoreductase. Other names in common use include cortisone reductase, (R)-20-hydroxysteroid dehydrogenase, dehydrogenase, 20beta-hydroxy steroid, Delta4-3-ketosteroid hydrogenase, 20beta-hydroxysteroid dehydrogenase, 3alpha,20beta-hydroxysteroid:NAD⁺-oxidoreductase, NADH-20beta-hydroxysteroid dehydrogenase, and 20beta-HSD. This enzyme participates in bile acid biosynthesis and c21-steroid hormone metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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