3-hydroxypropionate dehydrogenase (NADP+)
Template:Infobox enzyme 3-hydroxypropionate dehydrogenase (NADP+) (Template:EC number) is an enzyme with systematic name 3-hydroxypropionate:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- 3-hydroxypropionate + NADP+ malonate semialdehyde + NADPH + H+
This enzyme catalyses the reduction of malonate semialdehyde to 3-hydroxypropionate, which is a key step in the 3-hydroxypropionate and the 3-hydroxypropionate/4-hydroxybutyrate cycles, autotrophic CO2 fixation pathways found in some green non-sulfur phototrophic bacteria and archaea, respectively. The enzyme from Chloroflexus aurantiacus is bifunctional, and also catalyses the upstream reaction in the pathway, EC 1.2.1.75. Different from EC 1.1.1.59, 3-hydroxypropionate dehydrogenase (NAD+), by cofactor preference.
References
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