3-Hydroxybutyryl-CoA dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a 3-hydroxybutyryl-CoA dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

(S)-3-hydroxybutanoyl-CoA + NADP⁺ $\rightleftharpoons$ 3-acetoacetyl-CoA + NADPH + H⁺

Thus, the two substrates of this enzyme are (S)-3-hydroxybutanoyl-CoA and NADP⁺; its 3 products are acetoacetyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, to be specific those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (S)-3-hydroxybutanoyl-CoA:NADP⁺ oxidoreductase. Other names in common use include beta-hydroxybutyryl coenzyme A dehydrogenase, L-(+)-3-hydroxybutyryl-CoA dehydrogenase, BHBD, dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine, dinucleotide phosphate), L-(+)-3-hydroxybutyryl-CoA dehydrogenase, and beta-hydroxybutyryl-CoA dehydrogenase. This enzyme participates in benzoate degradation via coa ligation and butanoate metabolism.

• 
  Beta-hydroxybutyryl-CoA
• 
  Acetoacetyl-CoA

References

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