25-hydroxycholesterol 7α-hydroxylase

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Template:Short description Template:Infobox enzyme 25-hydroxycholesterol 7alpha-hydroxylase (Template:EC number, 25-hydroxycholesterol 7alpha-monooxygenase, CYP7B1, CYP7B1 oxysterol 7alpha-hydroxylase) is an enzyme with systematic name cholest-5-ene-3beta,25-diol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction

(1) cholest-5-ene-3beta,25-diol + NADPH + H+ + O2 ⇌ cholest-5-ene-3beta,7alpha,25-triol + NADP+ + H2O
(2) cholest-5-ene-3beta,27-diol + NADPH + H+ + O2 ⇌ cholest-5-ene-3beta,7alpha,27-triol + NADP+ + H2O

25-hydroxycholesterol 7α-hydroxylase is a heme-thiolate protein (P-450).

See also

References

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  1. ↑ Template:Cite journal
  2. ↑ Template:Cite journal
  3. ↑ Template:Cite journal
  4. ↑ Template:Cite journal
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