2-oxoaldehyde dehydrogenase (NAD+)

Template:Short description Template:Infobox enzyme In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (Template:EC number) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NAD⁺ + H₂O $\rightleftharpoons$ a 2-oxo acid + NADH + H⁺

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD⁺, and H₂O, whereas its 3 products are 2-oxo acid, NADH, and H⁺.

This enzyme participates in pyruvate metabolism.

Nomenclature

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include:

• alpha-ketoaldehyde dehydrogenase
• methylglyoxal dehydrogenase
• NAD+-linked alpha-ketoaldehyde dehydrogenase
• 2-ketoaldehyde dehydrogenase
• NAD+-dependent alpha-ketoaldehyde dehydrogenase
• 2-oxoaldehyde dehydrogenase (NAD+)

See also

• 2-oxoaldehyde dehydrogenase (NADP+)

References

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