2-Hydroxymuconate-6-semialdehyde dehydrogenase
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Template:Short description Template:Infobox enzyme 2-Hydroxymuconate-6-semialdehyde dehydrogenase (Template:EC number, Template:Proper name [gene], Template:Proper name [gene] ) is an enzyme with systematic name (2E,4Z)-2-hydroxy-6-oxohexa-2,4-dienoate:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- 2-hydroxymuconate-6-semialdehyde + NAD+ + H2O (2Z,4E)-2-hydroxyhexa-2,4-dienedioate + NADH + 2 H+
This substrate for this enzyme is formed by meta ring cleavage of catechol (EC 1.13.11.2, catechol 2,3-dioxygenase), and is an intermediate in the bacterial degradation of several aromatic compounds.
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