2-(R)-hydroxypropyl-CoM dehydrogenase

Template:Short description Template:Infobox enzyme In enzymology, a 2-(R)-hydroxypropyl-CoM dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction

2-(R)-hydroxypropyl-CoM + NAD⁺ $\rightleftharpoons$ 2-oxopropyl-CoM + NADH + H⁺

Thus, the two substrates of this enzyme are 2-(R)-hydroxypropyl-CoM and NAD⁺, whereas its 3 products are 2-oxopropyl-CoM, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 2-[2-(R)-hydroxypropylthio]ethanesulfonate:NAD⁺ oxidoreductase. This enzyme is also called 2-(2-(R)-hydroxypropylthio)ethanesulfonate dehydrogenase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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