(R)-2-hydroxyacid dehydrogenase
Template:Short description Template:Infobox enzyme In enzymology, a (R)-2-hydroxyacid dehydrogenase (Template:EC number) is an enzyme that catalyzes the chemical reaction
- (2R)-3-sulfolactate + NAD(P)Template:Sup 3-sulfopyruvate + NAD(P)H + HTemplate:Sup
The 3 substrates of this enzyme are (2R)-3-sulfolactic acid, [[nicotinamide adenine dinucleotide|NADTemplate:Sup]], and [[nicotinamide adenine dinucleotide phosphate|NADPTemplate:Sup]], whereas its 4 products are 3-sulfopyruvic acid, NADH, NADPH, and [[hydrogen ion|HTemplate:Sup]]. This enzyme is important in the metabolism of archaea, particularly their biosynthesis of coenzymes such as coenzyme M, tetrahydromethanopterin and methanofuran.[1]
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NADTemplate:Sup or NADPTemplate:Sup as acceptor. The systematic name of this enzyme class is (R)-2-hydroxyacid:NAD(P)Template:Sup oxidoreductase. Other names in common use include (R)-sulfolactate:NAD(P)Template:Sup oxidoreductase, L-sulfolactate dehydrogenase, ComC, and (R)-sulfolactate dehydrogenase.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.
References
Further reading
Template:Alcohol oxidoreductases Template:Enzymes Template:Portal bar