TRNA(His) guanylyltransferase
Template:Infobox enzyme tRNA(His) guanylyltransferase (Template:EC number, histidine tRNA guanylyltransferase, Thg1p, Thg1) is an enzyme with systematic name p-tRNA(His):GTP guanylyltransferase (ATP-hydrolysing).[1][2][3][4][5][6] This enzyme catalyses the following chemical reaction
- p-tRNA(His) + ATP + GTP pppGp-tRNA(His) + AMP + diphosphate (overall reaction)
- (1a) p-tRNA(His) + ATP App-tRNA(His) + diphosphate
- (1b) App-tRNA(His) + GTP pppGp-tRNA(His) + AMP
The enzyme requires a divalent cation for activity.