3-Isopropylmalate dehydrogenase

Template:Short description Template:Infobox enzyme 3-Isopropylmalate dehydrogenase (Template:EC number) is an enzyme that is a part of the isopropylmalate dehydrogenase family, which catalyzes the chemical reactions:

(2R,3S)-3-isopropylmalate + NAD⁺ $\rightleftharpoons$ 4-methyl-2-oxopentanoate + CO₂ + NADH

(2R,3S)-3-isopropylmalate + NAD⁺ $\rightleftharpoons$ (2S)-2-isopropyl-3-oxosuccinate + H⁺ + NADH

(2S)-2-isopropyl-3-oxosuccinate + H⁺ $\rightleftharpoons$ 4-methyl-2-oxopentanoate + CO₂

References

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