View source for Mannose-1-phosphate guanylyltransferase (GDP)

{{infobox enzyme
| Name       = mannose-1-phosphate guanylyltransferase (GDP)
| EC_number  = 2.7.7.22
| CAS_number = 9026-31-7
| GO_code    = 0008928
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''mannose-1-phosphate guanylyltransferase (GDP)''' ({{EC number|2.7.7.22}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:GDP + alpha-D-mannose 1-phosphate <math>\rightleftharpoons</math> phosphate + GDP-mannose

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[guanosine diphosphate|GDP]] and [[alpha-D-mannose 1-phosphate]], whereas its two [[product (chemistry)|products]] are [[phosphate]] and [[GDP-mannose]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing [[nucleotide]] groups ([[nucleotidyltransferase]]s).  The [[List of enzymes|systematic name]] of this enzyme class is '''GDP:alpha-D-mannose-1-phosphate guanylyltransferase'''. This enzyme participates in [[Fructose metabolism|fructose]] and [[mannose metabolism]].

==Other common names==
*GDP mannose phosphorylase
*Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase
*GDP mannose phosphorylase
*GDP-mannose 1-phosphate guanylyltransferase
*Guanosine diphosphate-mannose 1-phosphate guanylyltransferase
*Guanosine diphosphomannose phosphorylase
*Mannose 1-phosphate guanylyltransferase
*GDP:D-mannose-1-phosphate guanylyltransferase

==References==
{{reflist|1}}
* {{cite journal |vauthors=CARMINATTI H, CABIB E | date=  1961 | title = Phosphorolysis of the pyrophosphate bond of some nucleotides | journal = Biochim. Biophys. Acta  | volume = 53 | pages = 417&ndash;9  | pmid = 13876695 | doi = 10.1016/0006-3002(61)90458-9 | issue = 2 }}

{{Kinases}}
{{Enzymes}}
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[[Category:EC 2.7.7]]
[[Category:Enzymes of unknown structure]]


{{2.7-enzyme-stub}}