View source for Icosanoyl-CoA synthase

{{infobox enzyme
| Name       = Icosanoyl-CoA synthase
| EC_number  = 2.3.1.119
| CAS_number = 141256-55-5
| GO_code    =
| image      = 
| width      = 
| caption    =  
}}
In [[enzymology]], an '''icosanoyl-CoA synthase''' ({{EC number|2.3.1.119}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:stearoyl-CoA + malonyl-CoA + 2 NAD(P)H + 2 H<sup>+</sup> <math>\rightleftharpoons</math> icosanoyl-CoA + CO<sub>2</sub> + CoA + 2 NAD(P)+ + H<sub>2</sub>O

The 5 [[substrate (biochemistry)|substrates]] of this enzyme are [[stearoyl-CoA]], [[malonyl-CoA]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]], whereas its 6 [[product (chemistry)|products]] are [[icosanoyl-CoA]], [[carbon dioxide|CO<sub>2</sub>]], [[coenzyme A|CoA]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups.  The [[List of enzymes|systematic name]] of this enzyme class is '''stearoyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing)'''. Other names in common use include '''acyl-CoA elongase''', '''C18-CoA elongase''', and '''stearoyl-CoA elongase'''.

==References==
{{reflist|1}}
* {{cite journal |vauthors=Bessoule JJ, Lessire R, Cassagne C | date = 1989 | title = Partial purification of the acyl-CoA elongase of Allium porrum leaves | journal = Arch. Biochem. Biophys.  | volume = 268 | pages = 475&ndash;84  | pmid = 2913944 | doi = 10.1016/0003-9861(89)90315-9 | issue = 2 }}
* {{cite journal |vauthors=Bessoule JJ, Lessire R, Rigoulet M, Guerin B, Cassagne C | date = 1987 | title = Fatty acid synthesis in mitochondria from Saccharomyces cerevisiae | journal = FEBS Lett.  | volume = 214 | pages = 158&ndash;62  | pmid = 3552725 | doi = 10.1016/0014-5793(87)80033-9 | issue = 1 | doi-access = free }}
* {{cite journal |vauthors=Lessire R, Bessoule JJ, Cassagne C | date = 1985 | title = Solubilization of C18 CoA and C20 CoA elongases from Allium porrum L. epidermal-cell microsomes | journal = FEBS Lett.  | volume = 187 | pages = 314&ndash;320 | doi = 10.1016/0014-5793(85)81267-9 | issue = 2 | doi-access = free }}

{{Acyltransferases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 2.3.1]]
[[Category:NADPH-dependent enzymes]]
[[Category:NADH-dependent enzymes]]
[[Category:Enzymes of unknown structure]]


{{2.3-enzyme-stub}}