File:HIV Membrane fusion panel.svg

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    English: Mechanism of Viral Entry/Membrane Fusion

    1. Initial interaction between gp120 and CD4. 2. Conformational change in gp120 allows for secondary interaction with CXCR4. 3. The distal tips of gp41 are inserted in to the cellular membrane.

    4. gp41 undergoes significant conformational change; folding in half and forming coiled-coils. This process pulls the viral and cellular membranes together, fusing them.
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    Author Mike Jones
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    11 March 2013

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    Date/TimeThumbnailDimensionsUserComment
    current08:03, 3 November 2023Thumbnail for version as of 08:03, 3 November 20231,644 × 324 (2.09 MB)wikimediacommons>RasbakCCR5 replaced by CXCR4

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