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- ...ction, but the latter are primarily concerned with [[algorithm]]ic issues. Sequencing theory is based on elements of [[mathematics]], [[biology]], and [[systems ==Theory and sequencing strategies== ...22 KB (3,083 words) - 15:26, 7 November 2023
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- ...'': DNA is stained with a dye(green) that dissociates from single stranded DNA, changes in the environment like temperature increases that are not enough ...enfeldt J O; Flyvbjerg H. (2010). "Single-molecule denaturation mapping of DNA in nanofluidic channels". PNAS. doi: 10.1073</ref> ...7 KB (1,017 words) - 01:33, 3 July 2021
- {{short description|Measure of the completeness of DNA sequencing}} ...to achieve a read depth of 4.jpg|thumb|An overlap of the product of three sequencing runs, with the read sequence coverage at each point indicated.|270x270px]] ...8 KB (1,148 words) - 11:41, 1 November 2024
- ...last= Laird|first= Peter W.|year= 2003|title= The power and the promise of DNA methylation markers|journal= [[Nature Reviews Cancer]]|volume= 3|issue= Apr Genomic DNA of interest is treated with [[sodium bisulfite]], which introduces methylat ...12 KB (1,572 words) - 13:11, 5 June 2023
- ....A. et al. A Bayesian deconvolution strategy for immunoprecipitation-based DNA methylome analysis. ''Nature Biotechnology'' '''26''', 779–85 (2008).</ref> ...ll of which are methylated. As the antibody simply recognizes [[methylated DNA]], it will bind both these regions equally and subsequent steps will theref ...7 KB (1,120 words) - 02:31, 22 February 2020
- ...ults expose the strong influence of caps on flow profiles."</ref><br>[[DNA sequencing theory]] ...endl''' is a mathematician and biomedical engineer who has worked on [[DNA sequencing theory]],<ref>Dorman, N (2006) ''The long and short of it'', [[BioTechnique ...9 KB (1,292 words) - 00:06, 30 November 2024
- ...ction, but the latter are primarily concerned with [[algorithm]]ic issues. Sequencing theory is based on elements of [[mathematics]], [[biology]], and [[systems ==Theory and sequencing strategies== ...22 KB (3,083 words) - 15:26, 7 November 2023
- ...1=Hatice|last2=Lutz|first2=Jean-François|date=2014|title=Reading Polymers: Sequencing of Natural and Synthetic Macromolecules|url=https://onlinelibrary.wiley.com ==NMR-based sequencing== ...10 KB (1,303 words) - 16:52, 13 February 2023
- [[File:SCODA DNA concentration.png|thumb| Time-lapse sequence showing SYBR Green I - stained pUC19 DNA (2.7kb) being SCODA concentrated in the center of a 1% agarose gel (where n ...14 KB (2,139 words) - 01:40, 11 March 2023
- ...id=12045153 |pmc=186604 |doi-access=free}}</ref> and then adopted by other sequencing projects. As a result of this increasingly wide use, this format had alread ...ffected some formats such as FASTQ when [[List of sequenced animal genomes|sequencing projects]] multiplied at the beginning of the 21st century. ...14 KB (2,021 words) - 04:34, 9 September 2024
- ...Fourier transform|DFT]]-method for identifying protein-coding segments of DNA]] ...own by performing [[Fourier analysis]] on signals derived from segments of DNA sequences. Because of its predictive power, it has been used as a prelimina ...15 KB (2,413 words) - 09:15, 12 December 2023
- ...2011">{{cite journal |title=Genotype and SNP calling from next-generation sequencing data |author=Nielsen, R., Paul, J. S., Albrechtsen, A., and Song, Y. S. |jo ...method for the detection of variants from next-generation resequencing of DNA pools |author=Bansal, V. |journal=Bioinformatics |volume=26 |number=12 |pag ...23 KB (3,430 words) - 11:43, 6 February 2025
- ...re technology as a single-molecule tool to study how enzymes process along DNA or RNA.<ref>{{cite journal|doi=10.1038/nbt.3357|title= Subangstrom single-m * {{cite journal|doi=10.1073/pnas.0807514106|title=Single-molecule DNA detection with an engineered MspA protein nanopore |year=2008 |last1=Butler ...17 KB (2,239 words) - 16:23, 21 November 2024
- {{Short description|Single-cell sequencing technology}} ...to single-cell [[ATAC-seq|assay for transposase-accessible chromatin with sequencing]] (scATAC-seq), which only targets active [[euchromatin]],<ref>{{cite journ ...20 KB (2,629 words) - 12:43, 13 February 2024
- ...as Metallosphaera hakonensis comb. nov. based on phylogenetic evidence and DNA G+C content|journal=International Journal of Systematic and Evolutionary Mi ...s gene calling methods and [[Integrated Microbial Genomes System|IMG]]'s [[DNA annotation|annotation]] [[Pipeline (computing)|pipeline]]<ref name=":2" /> ...14 KB (1,974 words) - 00:22, 20 November 2024
- ...ous '''R'''ecombination '''D'''eficiency D'''etect''') is a [[whole-genome sequencing]] (WGS)-based classifier designed to predict [[BRCA1]] and [[BRCA2]] defici ...ing genome integrity, mainly through [[homologous recombination]] (HR) for DNA double-strand breaks (DSB)repair. The mutations of BRCA1 and BRCA2 can lead ...14 KB (2,003 words) - 08:59, 21 March 2024
- ...aligning many proteins, [[RNA]]s, or long genomic [[Nucleic acid sequence|DNA sequences]]. Along with [[MUSCLE (alignment software)|MUSCLE]] and [[MAFFT] FSA is currently being used for multiple projects, including sequencing new worm genomes and analyzing ''in vivo'' transcription factor binding in ...8 KB (1,129 words) - 20:43, 1 July 2024
- ...usly characterized genome, an attempt is made to align the newly sequenced DNA fragments to the existing genome sequence. As a simple example, consider the following [[Nucleic acid sequence|DNA sequences]]: ...17 KB (2,488 words) - 13:57, 29 November 2024
- ...site of RNA-protein crosslinks. Sequencing results of the [[Complementary DNA|cDNAs]] reveal information about both protein-RNA interaction networks and ...protein-RNA binding sites through peptide adduct-induced [[mutation]]s. [[Sequencing]] of the mutation-containing cDNA product will reveal the mutation sites (o ...15 KB (2,002 words) - 13:16, 22 February 2024
- ...SYBR Green is a very common dye that binds to DNA and is used to visualize DNA bands in an agarose gel. The dye absorbs blue light and fluoresces green fo ...n, Northern, and Southern): fluorochromes can bind to antibodies, RNA, and DNA to fluoresce and quantify data ...15 KB (2,171 words) - 17:52, 25 September 2024
- ...y are [[Natural environment|environmental]] in origin, and composed of the DNA from the whole [[Microbial community|community]] of [[Microorganism|microor ...pically fragmented in the form of many contigs, especially in [[Short-read sequencing|short-read]] assemblies where repeats and [[Transposon|integrative elements ...23 KB (3,039 words) - 17:34, 11 February 2025