Cobyrinate a,c-diamide synthase

Template:Infobox enzyme Cobyrinate a,c-diamide synthase (Template:EnzExplorer), cobyrinic acid a,c-diamide synthetase, CbiA (gene)) is an enzyme which catalyses the chemical reaction

2 ATP + cobyrinate + 2 L-glutamine + 2 H₂O $\rightleftharpoons$ 2 ADP + 2 phosphate + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)

(1a) ATP + cobyrinate + L-glutamine + H₂O $\rightleftharpoons$ ADP + phosphate + cobyrinate c-monamide + L-glutamate

(1b) ATP + cobyrinate c-monamide + L-glutamine + H₂O $\rightleftharpoons$ ADP + phosphate + cobyrinate a,c-diamide + L-glutamate

This enzyme is a glutamine amidotransferase, part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

• Cobalamin biosynthesis

External links

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