Cobalt-precorrin 5A hydrolase

Template:Infobox enzyme Cobalt-precorrin 5A hydrolase (Template:EC number), CbiG (gene)) is an enzyme with systematic name cobalt-precorrin 5A acylhydrolase. This enzyme catalyses the following chemical reaction

cobalt-precorrin-5A + H₂O $\rightleftharpoons$ cobalt-precorrin-5B + acetaldehyde + 2 H⁺

This enzyme hydrolyses the ring A acetate delta-lactone of cobalt-precorrin-5A and releases a two-carbon fragment from the macrocyclic corrin ring as acetaldehyde. This is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in anaerobic bacteria such as Salmonella typhimurium and Bacillus megaterium.

See also

• Cobalamin biosynthesis

External links

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