ADP-ribosylhydrolase 1
Template:Infobox enzyme (ADP-ribosyl)hydrolase 1, also termed [Protein ADP-ribosylarginine] hydrolase and protein-Nω-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase (Template:EC number), is an enzyme that in humans is encoded by the ADPRH gene.[1][2][3][4][5] This enzyme is a specific mono(ADP-ribosyl)hydrolase that catalyses the removal of an ADP-ribosyl modification from target arginine residues of protein substrates.[4][6] The chemical reactions can formally be described as follows:
- Nω-(ADP-D-ribosyl)-L-arginyl-[protein] + H2O ADP-D-ribose + L-arginyl-[protein]
- In addition, the enzyme can reverse the ADP-ribosylation of free arginine:[6][7][8]
- Nω-(ADP-D-ribosyl)-L-arginine + H2O ADP-D-ribose + L-arginine
See also
References
External links
Template:Sugar hydrolases Template:Enzymes Template:Portal bar