Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase

Template:Short description Template:Infobox enzyme Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase, that has two isoforms: SHIP1 (produced by the gene INPP5D) and SHIP2 (INPPL1).

This enzyme catalyses the following chemical reaction

1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + H₂O $\rightleftharpoons$
1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate + phosphate

This enzyme hydrolyses 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P₃) to produce PtdIns(3,4)P₂.

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