4-aminobutyrate—pyruvate transaminase
Template:Short description Template:Infobox enzyme 4-aminobutyrate---pyruvate transaminase (Template:EC number, aminobutyrate aminotransferase, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate transaminase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric transaminase, 4-aminobutyrate aminotransferase, 4-aminobutyric acid aminotransferase, aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, POP2 (gene)) is an enzyme with systematic name 4-aminobutanoate:pyruvate aminotransferase.[1][2][3][4] This enzyme is a type of GABA transaminase, which degrades the neurotransmitter GABA. The enzyme catalyses the following chemical reaction
- (1) 4-aminobutanoate + pyruvate succinate semialdehyde + L-alanine
- (2) 4-aminobutanoate + glyoxylate succinate semialdehyde + glycine
This enzyme requires pyridoxal 5'-phosphate.
Clinical significance
Phenylethylidenehydrazine, the active metabolite of phenelzine, inhibits gamma-aminobutyric acid transaminase and subsequently increases GABA concentrations in the central nervous system. This may contribute to the notable anxiolytic effects of phenelzine.[5]
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External links
Template:Nitrogenous transferases Template:Enzymes Template:Portal bar