Trans-resveratrol di-O-methyltransferase

Template:Infobox enzyme Trans-resveratrol di-O-methyltransferase (Template:EC number, ROMT, resveratrol O-methyltransferase, pterostilbene synthase) is an enzyme with systematic name S-adenosyl-L-methionine:trans-resveratrol 3,5-O-dimethyltransferase. This enzyme catalyses the following chemical reaction

2 S-adenosyl-L-methionine + trans-resveratrol $\rightleftharpoons$ 2 S-adenosyl-L-homocysteine + pterostilbene (overall reaction)

(1a) S-adenosyl-L-methionine + trans-resveratrol $\rightleftharpoons$ S-adenosyl-L-homocysteine + 3-methoxy-4',5-dihydroxy-trans-stilbene

(1b) S-adenosyl-L-methionine + 3-methoxy-4',5-dihydroxy-trans-stilbene $\rightleftharpoons$ S-adenosyl-L-homocysteine + pterostilbene

The enzyme catalyses the biosynthesis of pterostilbene from resveratrol.

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