TRNA:m4X modification enzyme

Template:Infobox enzyme TRNA:m4X modification enzyme (Template:EC number, TRM13, Trm13p, tRNA:Xm4 modification enzyme) is an enzyme with systematic name S-adenosyl-L-methionine:tRNAPro/His/Gly(GCC) (cytidine/adenosine4-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

(1) S-adenosyl-L-methionine + cytidine⁴ in tRNAPro $\rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine⁴ in tRNAPro

(2) S-adenosyl-L-methionine + cytidine⁴ in tRNAGly(GCC) $\rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine⁴ in tRNAGly(GCC)

(3) S-adenosyl-L-methionine + adenosine⁴ in tRNAHis $\rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methyladenosine⁴ in tRNAHis

The enzyme from Saccharomyces cerevisiae 2'-O-methylates cytidine⁴ in tRNAPro and tRNAGly(GCC), and adenosine⁴ in tRNAHis.

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