23S rRNA (uridine2479-2'-O)-methyltransferase

Template:Short description Template:Infobox enzyme 23S rRNA (uridine²⁴⁷⁹-2'-O)-methyltransferase (Template:EC number, AviRb) is an enzyme with systematic name S-adenosyl-L-methionine:23S rRNA (uridine²⁴⁷⁹-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + uridine²⁴⁷⁹ in 23S rRNA $\rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methyluridine²⁴⁷⁹ in 23S rRNA

Streptomyces viridochromogenes produces the antibiotic avilamycin A which binds to the 50S ribosomal subunit to inhibit protein synthesis.

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