TRNA (cytidine32/guanosine34-2'-O)-methyltransferase

Template:Infobox enzyme TRNA (cytidine³²/guanosine³⁴-2'-O)-methyltransferase (Template:EC number, Trm7p) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (cytidine32/guanosine34-2'-O)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + cytidine³²/guanosine³⁴ in tRNA $\rightleftharpoons$ S-adenosyl-L-homocysteine + 2'-O-methylcytidine³²/2'-O-methylguanosine³⁴ in tRNA

The enzyme from Saccharomyces cerevisiae catalyses the formation of 2'-O-methylnucleotides at positions 32 and 34 of the yeast tRNAPhe and tRNATrp.

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