16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase

Template:Short description Template:Infobox enzyme 16S rRNA (adenine¹⁵¹⁸-N⁶/adenine¹⁵¹⁹-N⁶)-dimethyltransferase (Template:EC number, S-adenosylmethionine-6-N',N'-adenosyl (rRNA) dimethyltransferase, KsgA, ksgA methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine¹⁵¹⁸-N⁶/adenine¹⁵¹⁹-N⁶)-dimethyltransferase. This enzyme catalyses the following chemical reaction

4 S-adenosyl-L-methionine + adenine¹⁵¹⁸/adenine¹⁵¹⁹ in 16S rRNA $\rightleftharpoons$ 4 Ribosomal RNA + N⁶-dimethyladenine¹⁵¹⁸/N⁶-dimethyladenine¹⁵¹⁹ in 16S rRNA

KsgA introduces the dimethylation of adenine¹⁵¹⁸ and adenine¹⁵¹⁹ in 16S rRNA. Strains lacking the methylase are resistant to kasugamycin [1].

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