Glycine/sarcosine/dimethylglycine N-methyltransferase

Template:Infobox enzyme Glycine/sarcosine/dimethylglycine N-methyltransferase (Template:EC number, GSDMT, glycine sarcosine dimethylglycine N-methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:glycine(or sarcosine or N,N-dimethylglycine) N-methyltransferase (sarcosine(or N,N-dimethylglycine or betaine)-forming). This enzyme catalyses the following chemical reaction

3 S-adenosyl-L-methionine + glycine $\rightleftharpoons$ 3 S-adenosyl-L-homocysteine + betaine (overall reaction)

(1a) S-adenosyl-L-methionine + glycine $\rightleftharpoons$ S-adenosyl-L-homocysteine + sarcosine

(1b) S-adenosyl-L-methionine + sarcosine $\rightleftharpoons$ S-adenosyl-L-homocysteine + N,N-dimethylglycine

(1c) S-adenosyl-L-methionine + N,N-dimethylglycine $\rightleftharpoons$ S-adenosyl-L-homocysteine + betaine

This enzyme from the halophilic methanoarchaeon Methanohalophilus portucalensis can methylate glycine and all of its intermediates to form the compatible solute trimethylglycine.

External links

• Template:MeshName