Tryptophan N-monooxygenase
Template:Short description Template:Infobox enzyme Tryptophan N-monooxygenase (Template:EC number, tryptophan N-hydroxylase, CYP79B1, CYP79B2, CYP79B3) is an enzyme with systematic name L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-tryptophan + 2 O2 + 2 NADPH + 2 H+ (E)-indol-3-ylacetaldoxime + 2 NADP+ + CO2 + 3 H2O (overall reaction)
- (1a) L-tryptophan + O2 + NADPH + H+ N-hydroxy-L-tryptophan + NADP+ + H2O
- (1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ N,N-dihydroxy-L-tryptophan + NADP+ + H2O
- (1c) N,N-dihydroxy-L-tryptophan (E)-indol-3-ylacetaldoxime + CO2 + H2O
Tryptophan N-monooxygenase is a heme-thiolate protein (P-450).