FAD-dependent urate hydroxylase
Template:Short description Template:Infobox enzyme FAD-dependent urate hydroxylase (Template:EC number, HpxO enzyme, FAD-dependent urate oxidase, urate hydroxylase) is an enzyme with systematic name urate,NADH:oxygen oxidoreductase (5-hydroxyisourate forming).[1] [2] A non-homologous isofunctional enzyme (NISE) to HpxO was found, and named HpyO.[3] HpyO was determined to be a typical Michaelian enzyme. These FAD-dependent urate hydroxylases are flavoproteins.
This enzyme catalyses the following chemical reaction
- urate + FADH + H+ + O2 5-hydroxyisourate + FAD+ + H2O