Ketosteroid monooxygenase
Template:Short description Template:Infobox enzyme Ketosteroid monooxygenase (Template:EC number, steroid-ketone monooxygenase, progesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, ester-producing), 17alpha-hydroxyprogesterone, NADPH2:oxygen oxidoreductase (20-hydroxylating, side-chain cleaving), androstenedione, NADPH2:oxygen oxidoreductase (17-hydroxylating, lactonizing)) is an enzyme with systematic name ketosteroid,NADPH:oxygen oxidoreductase (20-hydroxylating, ester-producing/20-hydroxylating, side-chain cleaving/17-hydroxylating, lactonizing).[1][2][3] This enzyme catalyses the following chemical reaction
- ketosteroid + NADPH + H+ + O2 steroid ester/lactone + NADP+ + H2O (general reaction)
- (1) progesterone + NADPH + H+ + O2 testosterone acetate + NADP+ + H2O
- (2) androstenedione + NADPH + H+ + O2 testololactone + NADP+ + H2O
- (3) 17alpha-hydroxyprogesterone + NADPH + H+ + O2 androstenedione + acetate + NADP+ + H2O
Ketosteroid monooxygenase is a single FAD-containing enzyme that catalyses three types of monooxygenase reaction.