DNA oxidative demethylase

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Template:Infobox enzyme DNA oxidative demethylase (Template:EC number, alkylated DNA repair protein, alpha-ketoglutarate-dependent dioxygenase ABH1, alkB (gene)) is an enzyme with systematic name methyl DNA-base, 2-oxoglutarate:oxygen oxidoreductase (formaldehyde-forming).[1][2][3] This enzyme catalyses the following chemical reaction

DNA-base-CH3 + 2-oxoglutarate + O2 ⇌ DNA-base + formaldehyde + succinate + CO2

DNA oxidative demethylase contains iron; activity is somewhat stimulated by ascorbate.

References

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Template:Dioxygenases Template:Enzymes Template:Portal bar


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  1. ↑ Template:Cite journal
  2. ↑ Template:Cite journal
  3. ↑ Template:Cite journal
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