Lysine 6-dehydrogenase
Template:Infobox enzyme Lysine 6-dehydrogenase (Template:EC number, L-lysine epsilon-dehydrogenase, L-lysine 6-dehydrogenase, LysDH) is an enzyme with systematic name L-lysine:NAD+ 6-oxidoreductase (deaminating).[1][2][3][4] This enzyme catalyses the following chemical reaction
- L-lysine + NAD+ (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NADH + H+ + NH3 (overall reaction)
- (1a) L-lysine + NAD+ + H2O (S)-2-amino-6-oxohexanoate + NADH + H+ + NH3
- (1b) (S)-2-amino-6-oxohexanoate (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous)
The enzyme is highly specific for L-lysine as substrate, although S-(2-aminoethyl)-L-cysteine can act as a substrate, but more slowly.
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Template:CH-NH2 oxidoreductases Template:Enzymes Template:Portal bar