4-Hydroxy-3-methylbut-2-enyl diphosphate reductase
Template:Short description Template:Infobox enzyme 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (Template:EC number, isopentenyl-diphosphate:NADP+ oxidoreductase, LytB, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase, HMBPP reductase, IspH, LytB/IspH) is an enzyme in the non-mevalonate pathway. It acts upon (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (or "HMB-PP").[1][2][3][4][5][6]
- (1) isopentenyl diphosphate + NAD(P)+ + H2O (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
- (2) dimethylallyl diphosphate + NAD(P)+ + H2O (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
4-Hydroxy-3-methylbut-2-enyl diphosphate reductase is an iron-sulfur protein that contains either a [3Fe-4S] or a [4Fe-4S] cluster.
References
Template:Non-mevalonate pathway enzymes Template:Other oxidoreductases Template:Enzymes Template:Portal bar