Lipopolysaccharide 3-alpha-galactosyltransferase

Template:Short description Template:Infobox enzyme In enzymology, a lipopolysaccharide 3-alpha-galactosyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

UDP-galactose + lipopolysaccharide $\rightleftharpoons$ UDP + 3-alpha-D-galactosyl-[lipopolysaccharide glucose]

Thus, the two substrates of this enzyme are UDP-galactose and lipopolysaccharide, whereas its two products are UDP and [[3-alpha-D-galactosyl-[lipopolysaccharide glucose]]].

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase. Other names in common use include UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase, UDP-galactose:polysaccharide galactosyltransferase, uridine diphosphate galactose:lipopolysaccharide, alpha-3-galactosyltransferase, uridine diphosphogalactose-lipopolysaccharide, and alpha,3-galactosyltransferase. This enzyme participates in lipopolysaccharide biosynthesis and glycan structures - biosynthesis 2.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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