Globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase

Template:Short description Template:Infobox enzyme In enzymology, a globotriaosylceramide 3-beta-N-acetylgalactosaminyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-galactosamine + alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl- (11)-ceramide

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UDP + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)- beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide

The 3 substrates of this enzyme are UDP-N-acetyl-D-galactosamine, [[alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-]], and (11)-ceramide, whereas its 3 products are UDP, [[N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-]], and [[beta-D-galactosyl-(1->4)-beta-D-glucosyl-(11)-ceramide]].

Wrongly characterized previously as globotriosylceramide beta-1,6-N-acetylgalactosaminyl-transferase (Template:EC number^[1]

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-galactosamine:alpha-D-galactosyl-(1->4)-beta-D-galact osyl-(1->4)-beta-D-glucosyl-(11)-ceramide III3-beta-N-acetyl-D-galactosaminyltransferase. This enzyme participates in glycosphingolipid biosynthesis - globoseries and glycan structures - biosynthesis 2.