4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase

Template:Short description Template:Infobox enzyme In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

GDP-beta-L-fucose + 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R $\rightleftharpoons$ GDP + 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl- R

Thus, the two substrates of this enzyme are GDP-beta-L-fucose and 1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R. Its 3 products are GDP, 1,4-beta-D-galactosyl-(alpha-1,3-L-fucosyl)-N-acetyl-D-glucosaminyl-, and R.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase. Other names in common use include:

• Lewis-negative alpha-3-fucosyltransferase
• plasma alpha-3-fucosyltransferase
• guanosine diphosphofucose-glucoside alpha1→3-fucosyltransferase
• galactoside 3-fucosyltransferase
• GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R
• 3-L-fucosyltransferase
• GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R, and
• 3-L-fucosyltransferase

This enzyme participates in 3 metabolic pathways: glycosphingolipid biosynthesis - neo-lactoseries, glycosphingolipid biosynthesis - globoseries, and glycan structures - biosynthesis 2.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

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• Template:Cite book
• Template:Cite journal

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