Methenyltetrahydrofolate cyclohydrolase

Template:Infobox enzyme In enzymology, a methenyltetrahydrofolate cyclohydrolase (Template:EC number) is an enzyme that catalyzes the chemical reaction

5,10-methenyltetrahydrofolate + H₂O $\rightleftharpoons$ 10-formyltetrahydrofolate

Thus, the two substrates of this enzyme are 5,10-methenyltetrahydrofolate and H₂O, whereas its product is 10-formyltetrahydrofolate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines.

This enzyme participates in glyoxylate and dicarboxylate metabolism and one carbon pool by folate.

Synonyms

The systematic name of this enzyme class is 5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing).

Other names in common use include:

• Citrovorum factor cyclodehydrase
• cyclohydrolase
• formyl-methenyl-methylenetetrahydrofolate synthetase (combined).

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal
• Template:Cite journal

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