Hydroxyisourate hydrolase

Template:Infobox enzyme In enzymology, a hydroxyisourate hydrolase (Template:EC number) is an enzyme that catalyzes the chemical reaction

5-hydroxyisourate + H₂O $\rightleftharpoons$ 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate

Thus, the two substrates of this enzyme are 5-hydroxyisourate and H₂O, whereas its product is 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 5-hydroxyisourate amidohydrolase. Other names in common use include HIUHase, and 5-hydroxyisourate hydrolase. This enzyme participates in purine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

See also

• 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase

References

• Template:Cite journal
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