Glutamin-(asparagin-)ase

Template:Infobox enzymeTemplate:Inline citations In enzymology, a glutamin-(asparagin-)ase (Template:EC number) is an enzyme that catalyzes the chemical reaction

L-glutamine + H₂O $\rightleftharpoons$ L-glutamate + NH₃

Thus, the two substrates of this enzyme are L-glutamine and H₂O, whereas its two products are L-glutamate and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-glutamine(L-asparagine) amidohydrolase. This enzyme participates in 4 metabolic pathways: glutamate metabolism, alanine and aspartate metabolism, d-glutamine and d-glutamate metabolism, and nitrogen metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

• Template:Cite journal

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