Formimidoylglutamase

Template:Infobox enzyme In enzymology, a formimidoylglutamase (Template:EC number) is an enzyme that catalyzes the chemical reaction

N-formimidoyl-L-glutamate + H₂O $\rightleftharpoons$ L-glutamate + formamide

Thus, the two substrates of this enzyme are N-formimidoyl-L-glutamate and H₂O, whereas its two products are L-glutamate and formamide.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is N-formimidoyl-L-glutamate formimidoylhydrolase. Other names in common use include formiminoglutamase, N-formiminoglutamate hydrolase, and N-formimino-L-glutamate formiminohydrolase. This enzyme participates in histidine metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

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