Glucosylceramidase

Template:Infobox enzyme In enzymology, a glucosylceramidase (Template:EC number) is an enzyme that catalyzes the chemical reaction

D-glucosyl-N-acylsphingosine + H₂O $\rightleftharpoons$ D-glucose + N-acylsphingosine

Thus, the two substrates of this enzyme are D-glucosyl-N-acylsphingosine and H₂O, whereas its two products are D-glucose and N-acylsphingosine.

This enzyme belongs to the family of hydrolases, specifically those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is D-glucosyl-N-acylsphingosine glucohydrolase. Other names in common use include:

• psychosine hydrolase,
• glucosphingosine glucosylhydrolase,
• GlcCer-beta-glucosidase,
• beta-D-glucocerebrosidase,
• glucosylcerebrosidase,
• beta-glucosylceramidase,
• ceramide glucosidase,
• glucocerebrosidase,
• glucosylsphingosine beta-glucosidase,
• and glucosylsphingosine beta-D-glucosidase.

This enzyme participates in sphingolipid metabolism and degradation of glycan structures.

Human proteins containing this domain

• GBA belongs to Glycoside hydrolase family 30, GBA2 belongs to Glycoside hydrolase family 116.

Further reading

• Template:Cite journal
• Template:Cite journal

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