Alpha-ribazole phosphatase

Template:Infobox enzyme The primary biochemical reaction catalyzed by the enzyme adenosylcobalamin/α-ribazole phosphatase (formerly α-ribazole phosphatase) (EC 3.1.3.73) is

adenosylcobalamin 5′-phosphate + H₂O = coenzyme B₁₂ + phosphate

This enzyme can also catalyze the following reaction in vitro, however it is not the biologically relevant reaction

α-ribazole 5′-phosphate + H₂O $\rightleftharpoons$ α-ribazole + phosphate

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name is adenosylcobalamin/α-ribazole-5′-phosphate phosphohydrolase. This enzyme is also called CobC. It is part of the biosynthetic pathway to cobalamin (vitamin B₁₂) in bacteria.

See also

• Cobalamin biosynthesis

Structural studies

As of late 2007, 16 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

Template:3.1-enzyme-stub