Nucleotide diphosphatase

Template:Short description Template:Unreliable sourcesTemplate:Infobox enzyme In enzymology, a nucleotide diphosphatase (Template:EC numberTemplate:Dubious) is an enzyme that catalyzes the chemical reaction

a dinucleotide + H₂O $\rightleftharpoons$ 2 mononucleotides

Thus, the two substrates of this enzyme are dinucleotide and H₂O, whereas its product is mononucleotide.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dinucleotide nucleotidohydrolase. Other names in common use include nucleotide pyrophosphatase, and nucleotide-sugar pyrophosphatase. This enzyme participates in 5 metabolic pathways: purine metabolism, starch and sucrose metabolism, riboflavin metabolism, nicotinate and nicotinamide metabolism, and pantothenate and coa biosynthesis.

Structural studies

Template:As of, 5 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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