Dihydroxy-acid dehydratase

Template:Infobox enzyme The enzyme dihydroxy-acid dehydratase (Template:EnzExplorer) catalyzes the chemical reaction

2,3-dihydroxy-3-methylbutanoate $\rightleftharpoons$ 3-methyl-2-oxobutanoate + H₂O

This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.

Nomenclature

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include

• acetohydroxyacid dehydratase,
• α,β-dihydroxyacid dehydratase,
• 2,3-dihydroxyisovalerate dehydratase,
• α,β-dihydroxyisovalerate dehydratase,
• dihydroxy acid dehydrase,
• DHAD,
• and 2,3-dihydroxy-acid hydro-lyase.

Further reading

• Template:Cite journal
• Template:Cite journal

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