Tetrahydrofolate synthase
Template:Short description Template:Infobox enzyme In enzymology, a tetrahydrofolate synthase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction
- ATP + tetrahydropteroyl-[gamma-Glu]n + L-glutamate ADP + phosphate + tetrahydropteroyl-[gamma-Glu]n+1
The 3 substrates of this enzyme are ATP, [[tetrahydropteroyl-[gamma-Glu]n]], and L-glutamate, whereas its 3 products are ADP, phosphate, and [[tetrahydropteroyl-[gamma-Glu]n+1]].
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is tetrahydropteroyl-gamma-polyglutamate:L-glutamate gamma-ligase (ADP-forming). This enzyme participates in folate biosynthesis.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.
References
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