NAD+ synthase (glutamine-hydrolysing)
Template:Infobox enzyme In enzymology, a NAD+ synthase (glutamine-hydrolysing) (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction
- ATP + deamido-NAD+ + L-glutamine + H2O AMP + diphosphate + NAD+ + L-glutamate. In eukaryotes, this enzyme contains a glutaminase domain related to nitrilase.[1]
The substrates of this enzyme are ATP, deamido-NAD+, L-glutamine, and H2O, whereas its 4 products are AMP, diphosphate, NAD+, and glutamate [2]
This enzyme participates in glutamate metabolism and nicotinate and nicotinamide metabolism.
Nomenclature
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is deamido-NAD+:L-glutamine amido-ligase (AMP-forming).
References
Template:Ligases CO CS and CN Template:Enzymes Template:Portal bar