L-amino-acid alpha-ligase

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In enzymology, an L-amino-acid alpha-ligase (Template:EC number) is an enzyme that catalyzes the chemical reaction

ATP + an L-amino acid + an L-amino acid ADP + phosphate + L-aminoacyl-L-amino acid

Thus, the two substrates of this enzyme are ATP and L-amino acid, whereas its 3 products are ADP, phosphate, and L-aminoacyl-L-amino acid.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-amino acid:L-amino acid ligase (ADP-forming). Other names in common use include L-amino acid alpha-ligase, bacilysin synthetase, YwfE, and L-amino acid ligase.

References

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