Histidine—tRNA ligase

Template:Infobox enzyme In enzymology, a histidine-tRNA ligase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction

ATP + L-histidine + tRNAHis $\rightleftharpoons$ AMP + diphosphate + L-histidyl-tRNAHis

The 3 substrates of this enzyme are ATP, L-histidine, and tRNA(His), whereas its 3 products are AMP, diphosphate, and L-histidyl-tRNA(His).

This enzyme participates in histidine metabolism and aminoacyl-trna biosynthesis.

Nomenclature

Histidine—tRNA ligase belongs to the family of ligase enzymes, specifically those forming carbon-oxygen bonds in aminoacyl-tRNA and related compounds. The systematic name of this enzyme class is L-histidine:tRNAHis ligase (AMP-forming). Other names in common use include histidyl-tRNA synthetase, histidyl-transfer ribonucleate synthetase, and histidine translase.

See also

• Anti-Jo1

References

• Template:Cite journal

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