Dethiobiotin synthase

Template:Short description Template:Infobox enzyme In enzymology, a dethiobiotin synthase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction

ATP + 7,8-diaminononanoate + CO₂ $\rightleftharpoons$ ADP + phosphate + dethiobiotin

The 3 substrates of this enzyme are ATP, 7,8-diaminononanoate, and CO₂, whereas its 3 products are ADP, phosphate, and dethiobiotin.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming). This enzyme is also called desthiobiotin synthase. This enzyme participates in biotin metabolism.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, Template:PDB link, and Template:PDB link.

References

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