Biotin—(acetyl-CoA-carboxylase) ligase
Template:Short description Template:Infobox enzyme In enzymology, a biotin—[acetyl-CoA-carboxylase] ligase (Template:EnzExplorer) is an enzyme that catalyzes the chemical reaction
- ATP + biotin + apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] AMP + diphosphate + [acetyl-CoA:carbon-dioxide ligase (ADP-forming)]
The 3 substrates of this enzyme are ATP, biotin, and apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)], whereas its 3 products are AMP, diphosphate, and acetyl-CoA:carbon-dioxide ligase (ADP-forming).
This enzyme belongs to the family of ligases, specifically those forming generic carbon-nitrogen bonds.
This enzyme participates in biotin metabolism. This protein may use the morpheein model of allosteric regulation.[1]
Nomenclature
The systematic name of this enzyme class is biotin:apo-[acetyl-CoA:carbon-dioxide ligase (ADP-forming)] ligase (AMP-forming). Other names in common use include:
- biotin-[acetyl-CoA carboxylase] synthetase,
- biotin-[acetyl coenzyme A carboxylase] synthetase,
- acetyl coenzyme A holocarboxylase synthetase,
- acetyl CoA holocarboxylase synthetase,
- biotin:apocarboxylase ligase,
- biotin holoenzyme synthetase,
- and HCS.
References
Further reading
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