Scyllo-inosamine-4-phosphate amidinotransferase

In enzymology, a scyllo-inosamine-4-phosphate amidinotransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

L-arginine + 1-amino-1-deoxy-scyllo-inositol 4-phosphate $\rightleftharpoons$ L-ornithine + 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate

Thus, the two substrates of this enzyme are L-arginine and 1-amino-1-deoxy-scyllo-inositol 4-phosphate, whereas its two products are L-ornithine and 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate.

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the amidinotransferases. The systematic name of this enzyme class is L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase. Other names in common use include L-arginine:inosamine-P-amidinotransferase, inosamine-P amidinotransferase, L-arginine:inosamine phosphate amidinotransferase, and inosamine-phosphate amidinotransferase. This enzyme participates in streptomycin biosynthesis.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

• Template:Cite journal

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