Methionyl-tRNA formyltransferase

Template:Infobox enzyme In enzymology, a methionyl-tRNA formyltransferase (Template:EC number) is an enzyme that catalyzes the chemical reaction

10-formyltetrahydrofolate + L-methionyl-tRNA^fMet + H₂O $\rightleftharpoons$ tetrahydrofolate + N-formylmethionyl-tRNA^fMet

This enzyme belongs to the family of transferases that transfer one-carbon groups, specifically the hydroxymethyl-, formyl- and related transferases. The systematic name of this enzyme class is 10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase. This enzyme participates in three metabolic pathways: methionine metabolism, one carbon pool by folate, and aminoacyl-tRNA biosynthesis.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

• Template:Cite journal

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